김  정  렬 (Jung Ryul Kim)

Education (학력)

Ph.D. (2008)             Department of Orthpaedic Surgery, Jeonbuk National University, Korea

M.S. (2000)              Department of Orthpaedic Surgery, Jeonbuk National University, Korea

B.S. (1995)               Department of Medical Science, Jeonbuk National University, Korea

Professional Experience (경력)

2002-present      Professor, Department of Orthpaedic Surgery

Jeonbuk National University, Jeonju, Korea

2004-2006               Post-doc., Department of Orthpaedic Surgery, University of California, San Diego

San Diego, USA

Research Interests (연구분야)

· Ischemic bone disease

· Osteoporosis

· Pathophysiology of Bone and soft tisse tumors

Representative Publications

1. Zhang Z, Song Y, Wang SI, Ha SH, Jang KY, Park BH, Moon YJ, Kim JR. " Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR-RANKL Signaling" J Bone Miner Res.2021, 36(3):579-590

2. Zhang Z, Ha SH, Moon YJ, Hussein UK, Song Y, Kim KM, Park SH, Park HS, Park BH, Ahn AR, Lee SA, Ahn SJ, Kim JR, Jang KY. " Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma" J Exp Clin Cancer Res, 2020, 17;39(1):247.

3. Park SH, Kang MA, Moon YJ, Jang KY, Kim JR. Metformin coordinates osteoblast/osteoclast differentiation associated with ischemic osteonecrosis. Aging (Albany NY). 2020 Feb 11;12(6):4727-4741.

4. Kim KM, Hussein UK, Park SH, Kang MA, Moon YJ, Zhang Z, Song Y, Park HS, Bae JS, Park BH, Ha SH, Moon WS, Kim JR, Jang KY. FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas. J Exp Clin Cancer Res. 2019 Jun 18;38(1):267.

5. Park HJ, Bae JS, Kim KM, Moon YJ, Park SH, Ha SH, Hussein UK, Zhang Z, Park HS, Park BH, Moon WS, Kim JR, Jang KY. The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma. J Exp Clin Cancer Res. 2018 May 21;37(1):107.

6. Kim KM, Wagle S, Moon YJ, Wang SI, Park BH, Jang KY, Kim JR. Interferon β protects against avascular osteonecrosis through interleukin 6 inhibition and silent information regulator transcript-1 upregulation. Oncotarget. 2017 Dec 16;9(3):3562-3575.

7. Park SH, Lee J, Kang MA, Moon YJ, Wang SI, Kim KM, Park BH, Jang KY, Kim JR. Potential of l-thyroxine to differentiate osteoblast-like cells via Angiopoietin1. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1409-15.

8. Wagle S, Park SH, Kim KM, Moon YJ, Bae JS, Kwon KS, Park HS, Lee H, Moon WS, Kim JR, Jang KY. DBC1/CCAR2 is involved in the stabilization of androgen receptor and the progression of osteosarcoma. Sci Rep. 2015 Aug 7;5:13144.

9. Zhou L, Jang KY, Moon YJ, Wagle S, Kim KM, Lee KB, Park BH, Kim JR. Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet. Sci Rep. 2015 Mar 23;5:9397.

10. Zhou L, Yoon SJ, Jang KY, Moon YJ, Wagle S, Lee KB, Park BH, Kim JR. COMP-angiopoietin1 potentiates the effects of bone morphogenic protein-2 on ischemic necrosis of the femoral head in rats. PLoS One. 2014 Oct 17;9(10):e110593.